Human Pancreatic Polypeptide (PPY) activation kit by CRISPRa

CAT#: GA103738

PPY CRISPRa kit - CRISPR gene activation of human pancreatic polypeptide

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PPY
• Locus ID: 5539
• Kit Components:

  GA103738G1, Pancreatic Polypeptide gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103738G2, Pancreatic Polypeptide gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103738G3, Pancreatic Polypeptide gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001319209, NM_002722
• Synonyms: PNP
• Summary: 'This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded 95 aa preproprotein is synthesized in the pancreatic islets of Langerhans and proteolytically processed to generate two peptide products. These products include the active pancreatic hormone of 36 aa and an icosapeptide of unknown function. This hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]'