Human Parathyroid Hormone (PTH) activation kit by CRISPRa

CAT#: GA103905

PTH CRISPRa kit - CRISPR gene activation of human parathyroid hormone

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PTH
• Locus ID: 5741
• Kit Components:

  GA103905G1, Parathyroid Hormone gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103905G2, Parathyroid Hormone gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103905G3, Parathyroid Hormone gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000315, NM_001316352
• Synonyms: PTH1
• Summary: 'This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]'