Human Parathyroid hormone related protein (PTHLH) activation kit by CRISPRa

CAT#: GA103908

PTHLH CRISPRa kit - CRISPR gene activation of human parathyroid hormone like hormone

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PTHLH
• Locus ID: 5744
• Kit Components:

  GA103908G1, Parathyroid hormone related protein gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103908G2, Parathyroid hormone related protein gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103908G3, Parathyroid hormone related protein gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002820, NM_198964, NM_198965, NM_198966
• Synonyms: BDE2; HHM; PLP; PTHR; PTHRP
• Summary: 'The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone. [provided by RefSeq, Nov 2013]'