Human PTPRN2 activation kit by CRISPRa

CAT#: GA103943

PTPRN2 CRISPRa kit - CRISPR gene activation of human protein tyrosine phosphatase receptor type N2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PTPRN2
• Locus ID: 5799
• Kit Components:

  GA103943G1, PTPRN2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103943G2, PTPRN2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103943G3, PTPRN2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001308267, NM_001308268, NM_002847, NM_130842, NM_130843
• Synonyms: IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2
• Summary: 'This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]'