Human RAD21 activation kit by CRISPRa

CAT#: GA103998

RAD21 CRISPRa kit - CRISPR gene activation of human RAD21 cohesin complex component

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RAD21
• Locus ID: 5885
• Kit Components:

  GA103998G1, RAD21 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103998G2, RAD21 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103998G3, RAD21 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006265
• Synonyms: CDLS4; hHR21; HR21; HRAD21; MCD1; NXP1; SCC1
• Summary: 'The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. [provided by RefSeq, Jul 2008]'