Human Rapsyn (RAPSN) activation kit by CRISPRa

CAT#: GA104023

RAPSN CRISPRa kit - CRISPR gene activation of human receptor associated protein of the synapse

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RAPSN
• Locus ID: 5913
• Kit Components:

  GA104023G1, Rapsyn gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104023G2, Rapsyn gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104023G3, Rapsyn gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005055, NM_032645
• Synonyms: CMS4C; CMS11; FADS; RAPSYN; RNF205
• Summary: 'This gene encodes a member of a family of proteins that are receptor associated proteins of the synapse. The encoded protein contains a conserved cAMP-dependent protein kinase phosphorylation site, and plays a critical role in clustering and anchoring nicotinic acetylcholine receptors at synaptic sites by linking the receptors to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin. Mutations in this gene may play a role in postsynaptic congenital myasthenic syndromes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2011]'