Human RFC5 activation kit by CRISPRa

CAT#: GA104079

RFC5 CRISPRa kit - CRISPR gene activation of human replication factor C subunit 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RFC5
• Locus ID: 5985
• Kit Components:

  GA104079G1, RFC5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104079G2, RFC5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104079G3, RFC5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001130112, NM_001130113, NM_001206801, NM_007370, NM_181578, NM_001346815, NR_144504
• Synonyms: RFC36
• Summary: 'This gene encodes the smallest subunit of the replication factor C complex, which consists of five distinct subunits (140, 40, 38, 37, and 36 kDa) and is required for DNA replication. This subunit interacts with the C-terminal region of proliferating cell nuclear antigen and is required to open and load proliferating cell nuclear antigen onto DNA during S phase. It is a member of the AAA+ (ATPases associated with various cellular activities) ATPase family and forms a core complex with the 38 and 40 kDa subunits that possesses DNA-dependent ATPase activity. A related pseudogene has been identified on chromosome 9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]'