Human Ribonuclease A (RNASE1) activation kit by CRISPRa

CAT#: GA104112

RNASE1 CRISPRa kit - CRISPR gene activation of human ribonuclease A family member 1, pancreatic

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RNASE1
• Locus ID: 6035
• Kit Components:

  GA104112G1, Ribonuclease A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104112G2, Ribonuclease A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104112G3, Ribonuclease A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_002933, NM_198232, NM_198234, NM_198235
• Synonyms: RAC1; RIB1; RNS1
• Summary: 'This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]'