Human BRD2 activation kit by CRISPRa

CAT#: GA104119

BRD2 CRISPRa kit - CRISPR gene activation of human bromodomain containing 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BRD2
• Locus ID: 6046
• Kit Components:

  GA104119G1, BRD2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104119G2, BRD2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104119G3, BRD2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001113182, NM_001199455, NM_001199456, NM_001291986, NM_005104, NR_037625
• Synonyms: D6S113E; FSH; FSRG1; NAT; RING3; RNF3
• Summary: 'This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]'