Human SRC activation kit by CRISPRa

CAT#: GA104613

SRC CRISPRa kit - CRISPR gene activation of human SRC proto-oncogene, non-receptor tyrosine kinase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SRC
• Locus ID: 6714
• Kit Components:

  GA104613G1, SRC gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104613G2, SRC gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104613G3, SRC gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_005417, NM_198291
• Synonyms: ASV; c-SRC; p60-Src; SRC1; THC6
• Summary: 'This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]'