Human TRBP (TARBP2) activation kit by CRISPRa

CAT#: GA104752

TARBP2 CRISPRa kit - CRISPR gene activation of human TARBP2 subunit of RISC loading complex

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TARBP2
• Locus ID: 6895
• Kit Components:

  GA104752G1, TRBP gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104752G2, TRBP gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104752G3, TRBP gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004178, NM_134323, NM_134324
• Synonyms: LOQS; TRBP; TRBP1; TRBP2
• Summary: 'HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008]'