Human TIE2 (TEK) activation kit by CRISPRa

CAT#: GA104821

TEK CRISPRa kit - CRISPR gene activation of human TEK receptor tyrosine kinase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TEK
• Locus ID: 7010
• Kit Components:

  GA104821G1, TIE2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104821G2, TIE2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104821G3, TIE2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000459, NM_001290077, NM_001290078
• Synonyms: CD202B; TIE-2; TIE2; VMCM; VMCM1
• Summary: 'This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]'