Human TGF beta Receptor III (TGFBR3) activation kit by CRISPRa

CAT#: GA104856

TGFBR3 CRISPRa kit - CRISPR gene activation of human transforming growth factor beta receptor 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TGFBR3
• Locus ID: 7049
• Kit Components:

  GA104856G1, TGF beta Receptor III gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104856G2, TGF beta Receptor III gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104856G3, TGF beta Receptor III gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001195683, NM_001195684, NM_003243, NR_036634
• Synonyms: betaglycan; BGCAN
• Summary: 'This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]'