Human TNFRSF4 activation kit by CRISPRa

CAT#: GA105023

TNFRSF4 CRISPRa kit - CRISPR gene activation of human TNF receptor superfamily member 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TNFRSF4
• Locus ID: 7293
• Kit Components:

  GA105023G1, TNFRSF4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105023G2, TNFRSF4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105023G3, TNFRSF4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003327
• Synonyms: ACT35; CD134; IMD16; OX40; TXGP1L
• Summary: 'The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]'