Human XRCC3 activation kit by CRISPRa

CAT#: GA105175

XRCC3 CRISPRa kit - CRISPR gene activation of human X-ray repair cross complementing 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: XRCC3
• Locus ID: 7517
• Kit Components:

  GA105175G1, XRCC3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105175G2, XRCC3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105175G3, XRCC3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001100118, NM_001100119, NM_005432
• Synonyms: CMM6
• Summary: 'This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]'