Human ALDH5A1 activation kit by CRISPRa

CAT#: GA105353

ALDH5A1 CRISPRa kit - CRISPR gene activation of human aldehyde dehydrogenase 5 family member A1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ALDH5A1
• Locus ID: 7915
• Kit Components:

  GA105353G1, ALDH5A1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105353G2, ALDH5A1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105353G3, ALDH5A1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001080, NM_170740, NM_001368954
• Synonyms: SSADH; SSDH
• Summary: This protein belongs to the aldehyde dehydrogenase family of proteins. This gene encodes a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA). In response to the defect, physiologic fluids from patients accumulate GHB, a compound with numerous neuromodulatory properties. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]