Human MADCAM1 activation kit by CRISPRa

CAT#: GA105428

MADCAM1 CRISPRa kit - CRISPR gene activation of human mucosal vascular addressin cell adhesion molecule 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MADCAM1
• Locus ID: 8174
• Kit Components:

  GA105428G1, MADCAM1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105428G2, MADCAM1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105428G3, MADCAM1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_130760, NM_130761, NM_130762
• Synonyms: MACAM1
• Summary: The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]