Human Caspr (CNTNAP1) activation kit by CRISPRa

CAT#: GA105624

CNTNAP1 CRISPRa kit - CRISPR gene activation of human contactin associated protein 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CNTNAP1
• Locus ID: 8506
• Kit Components:

  GA105624G1, CNTNAP1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105624G2, CNTNAP1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105624G3, CNTNAP1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003632
• Synonyms: CASPR; CNTNAP; NRXN4; P190
• Summary: The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. [provided by RefSeq, Jan 2009]