Human RFXANK activation kit by CRISPRa

CAT#: GA105711

RFXANK CRISPRa kit - CRISPR gene activation of human regulatory factor X associated ankyrin containing protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RFXANK
• Locus ID: 8625
• Kit Components:

  GA105711G1, RFXANK gRNA vector 1 in pCas-Guide-CRISPRa

  GA105711G2, RFXANK gRNA vector 2 in pCas-Guide-CRISPRa

  GA105711G3, RFXANK gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001278727, NM_001278728, NM_003721, NM_134440, NM_001370233, NM_001370235, NM_001370237, NM_001370238, NM_001370234, NM_001370236
• Synonyms: ANKRA1; BLS; F14150_1; RFX-B
• Summary: Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. This protein contains ankyrin repeats involved in protein-protein interactions. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2013]