Human SIGLEC5 activation kit by CRISPRa

CAT#: GA105829

SIGLEC5 CRISPRa kit - CRISPR gene activation of human sialic acid binding Ig like lectin 5

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SIGLEC5
• Locus ID: 8778
• Kit Components:

  GA105829G1, SIGLEC5 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105829G2, SIGLEC5 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105829G3, SIGLEC5 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_003830
• Synonyms: CD33L2; CD170; OB-BP2; OBBP2; SIGLEC-5
• Summary: This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012]