Human MSK2 / RSK-B (RPS6KA4) activation kit by CRISPRa

CAT#: GA105974

RPS6KA4 CRISPRa kit - CRISPR gene activation of human ribosomal protein S6 kinase A4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: RPS6KA4
• Locus ID: 8986
• Kit Components:

  GA105974G1, RPS6KA4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA105974G2, RPS6KA4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA105974G3, RPS6KA4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001006944, NM_001300802, NM_003942, NM_001318361
• Synonyms: MSK2; RSK-B
• Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]