Human TAF1C activation kit by CRISPRa

CAT#: GA105988

TAF1C CRISPRa kit - CRISPR gene activation of human TATA-box binding protein associated factor, RNA polymerase I subunit C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TAF1C
• Locus ID: 9013
• Kit Components:

  GA105988G1, TAF1C gRNA vector 1 in pCas-Guide-CRISPRa

  GA105988G2, TAF1C gRNA vector 2 in pCas-Guide-CRISPRa

  GA105988G3, TAF1C gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001243156, NM_001243157, NM_001243158, NM_001243159, NM_001243160, NM_005679, NM_139353
• Synonyms: MGC:39976; SL1; TAFI95; TAFI110
• Summary: Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]