Human LRAT activation kit by CRISPRa

CAT#: GA106152

LRAT CRISPRa kit - CRISPR gene activation of human lecithin retinol acyltransferase

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LRAT
• Locus ID: 9227
• Kit Components:

  GA106152G1, LRAT gRNA vector 1 in pCas-Guide-CRISPRa

  GA106152G2, LRAT gRNA vector 2 in pCas-Guide-CRISPRa

  GA106152G3, LRAT gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001301645, NM_004744
• Synonyms: LCA14
• Summary: The protein encoded by this gene localizes to the endoplasmic reticulum, where it catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester. This reaction is an important step in vitamin A metabolism in the visual system. Mutations in this gene have been associated with early-onset severe retinal dystrophy and Leber congenital amaurosis 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]