Human TRIP12 activation kit by CRISPRa

CAT#: GA106211

TRIP12 CRISPRa kit - CRISPR gene activation of human thyroid hormone receptor interactor 12

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TRIP12
• Locus ID: 9320
• Kit Components:

  GA106211G1, TRIP12 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106211G2, TRIP12 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106211G3, TRIP12 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001284214, NM_001284215, NM_001284216, NM_004238, NM_001348315, NM_001348316, NM_001348317, NM_001348318, NM_001348319, NM_001348320, NM_001348321, NM_001348322, NM_001348323, NM_001348324, NM_001348325, NM_001348326, NM_001348327, NM_001348328, NM_001348329, NM_001348330, NM_001348331, NM_001348332, NM_001348333, NM_001348334, NM_001348335, NM_001348336
• Synonyms: TRIP-12; ULF
• Summary: The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]