Human LONP1 activation kit by CRISPRa

CAT#: GA106242

LONP1 CRISPRa kit - CRISPR gene activation of human lon peptidase 1, mitochondrial

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LONP1
• Locus ID: 9361
• Kit Components:

  GA106242G1, LONP1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106242G2, LONP1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106242G3, LONP1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001276479, NM_001276480, NM_004793, NR_076392
• Synonyms: CODASS; hLON; LON; LonHS; LONP; PIM1; PRSS15
• Summary: This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]