Human HOMER3 activation kit by CRISPRa

CAT#: GA106314

HOMER3 CRISPRa kit - CRISPR gene activation of human homer scaffold protein 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: HOMER3
• Locus ID: 9454
• Kit Components:

  GA106314G1, HOMER3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106314G2, HOMER3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106314G3, HOMER3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001145721, NM_001145722, NM_001145724, NM_004838, NR_027297
• Synonyms: HOMER-3; VESL3
• Summary: This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]