Human MTRF1 activation kit by CRISPRa

CAT#: GA106439

MTRF1 CRISPRa kit - CRISPR gene activation of human mitochondrial translation release factor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MTRF1
• Locus ID: 9617
• Kit Components:

  GA106439G1, MTRF1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106439G2, MTRF1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106439G3, MTRF1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_004294, NM_001354073, NM_001354074, NM_001354075, NM_001354076
• Synonyms: MRF1; MTTRF1; RF1
• Summary: The protein encoded by this gene was determined by in silico methods to be a mitochondrial protein with similarity to the peptide chain release factors (RFs) discovered in bacteria and yeast. The peptide chain release factors direct the termination of translation in response to the peptide chain termination codons. Initially thought to have a role in the termination of mitochondria protein synthesis, a recent publication found no mitochondrial translation release functionality. Multiple alternatively spliced transcript variants have been suggested by mRNA and EST data; however, their full-length natures are not clear. [provided by RefSeq, Jul 2008]