Human SAPS2 (PPP6R2) activation kit by CRISPRa

CAT#: GA106512

PPP6R2 CRISPRa kit - CRISPR gene activation of human protein phosphatase 6 regulatory subunit 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PPP6R2
• Locus ID: 9701
• Kit Components:

  GA106512G1, PPP6R2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106512G2, PPP6R2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106512G3, PPP6R2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001242898, NM_001242899, NM_001242900, NM_014678, NM_001351641, NM_001351642, NM_001351643, NM_001351644, NM_001351645, NM_001351646, NM_001351647, NM_001351648, NM_001365836
• Synonyms: KIAA0685; PP6R2; SAP190; SAPS2
• Summary: The protein encoded by this gene is a regulatory protein for the protein phosphatase-6 catalytic subunit. Together, these proteins act as a significant T-loop phosphatase for Aurora A, an essential mitotic kinase. Loss of function of either the regulatory or catalytic subunit of protein phosphatase-6 interferes with spindle formation and chromosome alignment. [provided by RefSeq, May 2017]