Human IL18BP activation kit by CRISPRa

CAT#: GA106823

IL18BP CRISPRa kit - CRISPR gene activation of human interleukin 18 binding protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: IL18BP
• Locus ID: 10068
• Kit Components:

  GA106823G1, IL18BP gRNA vector 1 in pCas-Guide-CRISPRa

  GA106823G2, IL18BP gRNA vector 2 in pCas-Guide-CRISPRa

  GA106823G3, IL18BP gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001039659, NM_001039660, NM_001145055, NM_001145057, NM_005699, NM_173042, NM_173043, NM_173044
• Synonyms: IL18BPa
• Summary: The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]