Human Perilipin 3 (PLIN3) activation kit by CRISPRa

CAT#: GA106955

PLIN3 CRISPRa kit - CRISPR gene activation of human perilipin 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PLIN3
• Locus ID: 10226
• Kit Components:

  GA106955G1, PLIN3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA106955G2, PLIN3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA106955G3, PLIN3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001164189, NM_001164194, NM_005817
• Synonyms: M6PRBP1; PP17; TIP47
• Summary: Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]