Human NCOA2 activation kit by CRISPRa

CAT#: GA107173

NCOA2 CRISPRa kit - CRISPR gene activation of human nuclear receptor coactivator 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: NCOA2
• Locus ID: 10499
• Kit Components:

  GA107173G1, NCOA2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107173G2, NCOA2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107173G3, NCOA2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001321703, NM_001321707, NM_001321711, NM_001321712, NM_001321713, NM_006540
• Synonyms: bHLHe75; GRIP1; KAT13C; NCoA-2; SRC2; TIF2
• Summary: The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]