Human Semaphorin 3c (SEMA3C) activation kit by CRISPRa

CAT#: GA107179

SEMA3C CRISPRa kit - CRISPR gene activation of human semaphorin 3C

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SEMA3C
• Locus ID: 10512
• Kit Components:

  GA107179G1, SEMA3C gRNA vector 1 in pCas-Guide-CRISPRa

  GA107179G2, SEMA3C gRNA vector 2 in pCas-Guide-CRISPRa

  GA107179G3, SEMA3C gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_006379, NM_001350120, NM_001350121
• Synonyms: SEMAE; SemE
• Summary: This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease. [provided by RefSeq, May 2017]