Human CFHR4 activation kit by CRISPRa

CAT#: GA107450

CFHR4 CRISPRa kit - CRISPR gene activation of human complement factor H related 4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: CFHR4
• Locus ID: 10877
• Kit Components:

  GA107450G1, CFHR4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107450G2, CFHR4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107450G3, CFHR4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001201550, NM_001201551, NM_006684
• Synonyms: CFHL4; FHR-4; FHR4
• Summary: This gene is a member of the complement factor H (CFH) gene family, and encodes one of the 5 CFH-related (CFHR) proteins. These 5 genes are closely linked to the CFH gene on chromosome 1q31-q32. The CFHRs are secreted plasma proteins synthesized primarily by the hepatocytes, and composed of highly-related short consensus repeats (SCRs). This protein enhances the cofactor activity of CFH, and is involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism. Alternatively spliced transcript variants encoding different isoforms (varying in the number of SCRs) have been described for this gene. [provided by RefSeq, Jan 2011]