Human Kindlin 2 (FERMT2) activation kit by CRISPRa

CAT#: GA107537

FERMT2 CRISPRa kit - CRISPR gene activation of human fermitin family member 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: FERMT2
• Locus ID: 10979
• Kit Components:

  GA107537G1, FERMT2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107537G2, FERMT2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107537G3, FERMT2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001134999, NM_001135000, NM_006832
• Synonyms: KIND2; mig-2; MIG2; PLEKHC1; UNC112; UNC112B
• Summary: Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. [UniProtKB/Swiss-Prot Function]