Human LILRB4 activation kit by CRISPRa

CAT#: GA107557

LILRB4 CRISPRa kit - CRISPR gene activation of human leukocyte immunoglobulin like receptor B4

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: LILRB4
• Locus ID: 11006
• Kit Components:

  GA107557G1, LILRB4 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107557G2, LILRB4 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107557G3, LILRB4 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001081438, NM_001278426, NM_001278427, NM_001278428, NM_001278429, NM_001278430, NM_006847
• Synonyms: CD85K; HM18; ILT3; LILRB5; LIR-5; LIR5
• Summary: This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]