Human SEC31A activation kit by CRISPRa

CAT#: GA107870

SEC31A CRISPRa kit - CRISPR gene activation of human SEC31 homolog A, COPII coat complex component

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SEC31A
• Locus ID: 22872
• Kit Components:

  GA107870G1, SEC31A gRNA vector 1 in pCas-Guide-CRISPRa

  GA107870G2, SEC31A gRNA vector 2 in pCas-Guide-CRISPRa

  GA107870G3, SEC31A gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001077206, NM_001077207, NM_001077208, NM_001191049, NM_001300744, NM_001300745, NM_001318119, NM_001318120, NM_014933, NM_016211
• Synonyms: ABP125; ABP130; HSPC275; HSPC334; SEC31L1
• Summary: The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]