Human POMZP3 activation kit by CRISPRa

CAT#: GA107923

POMZP3 CRISPRa kit - CRISPR gene activation of human POM121 and ZP3 fusion

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: POMZP3
• Locus ID: 22932
• Kit Components:

  GA107923G1, POMZP3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA107923G2, POMZP3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA107923G3, POMZP3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_012230, NM_152992
• Synonyms: POM-ZP3; POM121
• Summary: This gene appears to have resulted from a fusion of DNA sequences derived from 2 distinct loci, specifically through the duplication of two internal exons from the POM121 gene and four 3' exons from the ZP3 gene. The 5' end of this gene is similar to the 5` coding region of the POM121 gene which encodes an integral nuclear pore membrane protein. However, the protein encoded by this gene lacks the nuclear pore localization motif. The 3' end of this gene is similar to the last 4 exons of the zona pellucida glycoprotein 3 (ZP3) gene and the encoded protein retains one zona pellucida domain. Multiple protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]