Human SCRIBBLE (SCRIB) activation kit by CRISPRa

CAT#: GA108357

SCRIB CRISPRa kit - CRISPR gene activation of human scribble planar cell polarity protein

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SCRIB
• Locus ID: 23513
• Kit Components:

  GA108357G1, SCRIB gRNA vector 1 in pCas-Guide-CRISPRa

  GA108357G2, SCRIB gRNA vector 2 in pCas-Guide-CRISPRa

  GA108357G3, SCRIB gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_015356, NM_182706
• Synonyms: CRIB1; SCRB1; SCRIB1; Vartul
• Summary: This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]