Human SPO11 activation kit by CRISPRa

CAT#: GA108444

SPO11 CRISPRa kit - CRISPR gene activation of human SPO11 initiator of meiotic double stranded breaks

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: SPO11
• Locus ID: 23626
• Kit Components:

  GA108444G1, SPO11 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108444G2, SPO11 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108444G3, SPO11 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_012444, NM_198265
• Synonyms: CT35; SPATA43; TOPVIA
• Summary: Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]