Human BRMS1 activation kit by CRISPRa

CAT#: GA108589

BRMS1 CRISPRa kit - CRISPR gene activation of human BRMS1 transcriptional repressor and anoikis regulator

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: BRMS1
• Locus ID: 25855
• Kit Components:

  GA108589G1, BRMS1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108589G2, BRMS1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108589G3, BRMS1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001024957, NM_001024958, NM_015399
• Synonyms: DKFZp564A063
• Summary: This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]