Human C2CD3 activation kit by CRISPRa

CAT#: GA108689

C2CD3 CRISPRa kit - CRISPR gene activation of human C2 domain containing 3 centriole elongation regulator

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: C2CD3
• Locus ID: 26005
• Kit Components:

  GA108689G1, C2CD3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108689G2, C2CD3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108689G3, C2CD3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001286577, NM_015531
• Synonyms: OFD14
• Summary: This gene encodes a protein that functions as a regulator of centriole elongation. Studies of the orthologous mouse protein show that it promotes centriolar distal appendage assembly and is also required for the recruitment of other ciliogenic proteins, including intraflagellar transport proteins. Mutations in this gene cause orofaciodigital syndrome XIV (OFD14), a ciliopathy resulting in malformations of the oral cavity, face and digits. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]