Human SGEF (ARHGEF26) activation kit by CRISPRa

CAT#: GA108740

ARHGEF26 CRISPRa kit - CRISPR gene activation of human Rho guanine nucleotide exchange factor 26

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: ARHGEF26
• Locus ID: 26084
• Kit Components:

  GA108740G1, ARHGEF26 gRNA vector 1 in pCas-Guide-CRISPRa

  GA108740G2, ARHGEF26 gRNA vector 2 in pCas-Guide-CRISPRa

  GA108740G3, ARHGEF26 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001251962, NM_001251963, NM_015595
• Synonyms: CSGEF; HMFN1864; SGEF
• Summary: This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]