Human KCNMB3 activation kit by CRISPRa

CAT#: GA109004

KCNMB3 CRISPRa kit - CRISPR gene activation of human potassium calcium-activated channel subfamily M regulatory beta subunit 3

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: KCNMB3
• Locus ID: 27094
• Kit Components:

  GA109004G1, KCNMB3 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109004G2, KCNMB3 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109004G3, KCNMB3 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001163677, NM_014407, NM_171828, NM_171829, NM_171830, NR_028135
• Synonyms: BKBETA3; HBETA3; K(VCA)BETA-3; KCNMB2; KCNMBL; SLO-BETA-3; SLOBETA3
• Summary: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. [provided by RefSeq, Jul 2009]