Human OXGR1 activation kit by CRISPRa

CAT#: GA109063

OXGR1 CRISPRa kit - CRISPR gene activation of human oxoglutarate receptor 1

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: OXGR1
• Locus ID: 27199
• Kit Components:

  GA109063G1, OXGR1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109063G2, OXGR1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109063G3, OXGR1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001346194, NM_001346195, NM_001346196, NM_001346197, NM_080818
• Synonyms: aKGR; GPR80; GPR99; P2RY15; P2Y15
• Summary: This gene encodes a G protein-coupled receptor (GPCR) that belongs to the oxoglutarate receptor family within the GPCR superfamily. The encoded protein is activated by the citric acid intermediate, oxoglutarate, as well as several cysteinyl leukotrienes, including leukotrienes E4, C4 and D4, which are implicated in many inflammatory disorders. In mice, a knock-out of this gene leads to middle ear inflammation, changes in the mucosal epithelium, and an increase in fluid behind the eardrum, and is associated with hearing loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]