Human HIP55 (DBNL) activation kit by CRISPRa

CAT#: GA109193

DBNL CRISPRa kit - CRISPR gene activation of human drebrin like

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: DBNL
• Locus ID: 28988
• Kit Components:

  GA109193G1, DBNL gRNA vector 1 in pCas-Guide-CRISPRa

  GA109193G2, DBNL gRNA vector 2 in pCas-Guide-CRISPRa

  GA109193G3, DBNL gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001014436, NM_001122956, NM_001284313, NM_001284315, NM_014063, NM_001362723
• Synonyms: ABP1; HIP-55; HIP55; SH3P7
• Summary: Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. [UniProtKB/Swiss-Prot Function]