Human MDFIC activation kit by CRISPRa

CAT#: GA109350

MDFIC CRISPRa kit - CRISPR gene activation of human MyoD family inhibitor domain containing

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: MDFIC
• Locus ID: 29969
• Kit Components:

  GA109350G1, MDFIC gRNA vector 1 in pCas-Guide-CRISPRa

  GA109350G2, MDFIC gRNA vector 2 in pCas-Guide-CRISPRa

  GA109350G3, MDFIC gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001166345, NM_001166346, NM_199072
• Synonyms: HIC
• Summary: This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]