Human TMX2 activation kit by CRISPRa

CAT#: GA109541

TMX2 CRISPRa kit - CRISPR gene activation of human thioredoxin related transmembrane protein 2

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: TMX2
• Locus ID: 51075
• Kit Components:

  GA109541G1, TMX2 gRNA vector 1 in pCas-Guide-CRISPRa

  GA109541G2, TMX2 gRNA vector 2 in pCas-Guide-CRISPRa

  GA109541G3, TMX2 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001144012, NM_015959, NR_026593, NR_037645, NM_001347890, NM_001347891, NM_001347892, NM_001347893, NM_001347894, NM_001347895, NM_001347896, NM_001347898, NR_144933, NR_144934, NR_144935
• Synonyms: CGI-31; PDIA12; PIG26; TXNDC14
• Summary: This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This protein is enriched on the mitochondria-associated-membrane of the ER via palmitoylation of two of its cytosolically exposed cysteines. [provided by RefSeq, Jan 2017]