Human PGPEP1 activation kit by CRISPRa

CAT#: GA110317

PGPEP1 CRISPRa kit - CRISPR gene activation of human pyroglutamyl-peptidase I

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PGPEP1
• Locus ID: 54858
• Kit Components:

  GA110317G1, PGPEP1 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110317G2, PGPEP1 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110317G3, PGPEP1 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001300927, NM_001308366, NM_001329471, NM_001329476, NM_001329477, NM_001329478, NM_017712, NR_138029
• Synonyms: PAP-I; Pcp; PGI; PGP; PGP-I; PGPI
• Summary: The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression of this gene may be downregulated in colorectal cancer, while activity of the encoded protein may be negatively correlated with cancer progression in colorectal cancer patients. Activity of the encoded protease may also be altered in other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016]