Human PARP16 activation kit by CRISPRa

CAT#: GA110402

PARP16 CRISPRa kit - CRISPR gene activation of human poly(ADP-ribose) polymerase family member 16

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: PARP16
• Locus ID: 54956
• Kit Components:

  GA110402G1, PARP16 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110402G2, PARP16 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110402G3, PARP16 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001316943, NM_001316944, NM_017851
• Synonyms: ARTD15; C15orf30; pART15
• Summary: Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565). May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine, cysteine or glutamate residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565). [UniProtKB/Swiss-Prot Function]