Human INT11 (CPSF3L) activation kit by CRISPRa

CAT#: GA110418

INTS11 CRISPRa kit - CRISPR gene activation of human integrator complex subunit 11

Product Images

Specifications

Product Data

• Format: 3gRNAs, 1 scramble ctrl and 1 enhancer vector
• Symbol: INTS11
• Locus ID: 54973
• Kit Components:

  GA110418G1, INTS11 gRNA vector 1 in pCas-Guide-CRISPRa

  GA110418G2, INTS11 gRNA vector 2 in pCas-Guide-CRISPRa

  GA110418G3, INTS11 gRNA vector 3 in pCas-Guide-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100058

• Disclaimer: The kit is designed based on the best knowledge of CRISPa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001256456, NM_001256460, NM_001256462, NM_001256463, NM_017871, NM_032179
• Synonyms: CPSF73L; INT11; INTS11; RC-68; RC68
• Summary: The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]). [supplied by OMIM, Mar 2008]